Morphologic Changes due to Cutaneous Leishmaniosis in BALB/c Mice Experimentally Infected withLeishmania major
نویسندگان
چکیده
منابع مشابه
Major histocompatibility complex heterozygosity reduces fitness in experimentally infected mice.
It is often suggested that heterozygosity at major histocompatibility complex (MHC) loci confers enhanced resistance to infectious diseases (heterozygote advantage, HA, hypothesis), and overdominant selection should contribute to the evolution of these highly polymorphic genes. The evidence for the HA hypothesis is mixed and mainly from laboratory studies on inbred congenic mice, leaving the im...
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BACKGROUND Uncoupling protein 2 (UCP2) is a mitochondrial transporter that has been shown to lower the production of reactive oxygen species (ROS). Intracellular pathogens such as Leishmania upregulate UCP2 and thereby suppress ROS production in infected host tissues, allowing the multiplication of parasites within murine phagocytes. This makes host UCP2 and ROS production potential targets in ...
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ژورنال
عنوان ژورنال: Journal of Applied Animal Research
سال: 2008
ISSN: 0971-2119,0974-1844
DOI: 10.1080/09712119.2008.9706946